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- W2364758432 abstract "Objective:To study the influence of inhibitory polypeptide for CXCR4(NT21MP)on the expression of CXCR4 of the breast cancer cell strains SKBR3 and MCF-7 with different expression of HER-2 receptor.Methods:The expressions of HER-2 and CXCR4 in breast cancer cells MCF-7 and SKBR3 were detected by immunohistochemistry and RT-PCR;the two cells were treated by 1 μg /ml and 10 μg /ml NT21MP for 48 h;the expressions of CXCR4 mRNA and protein were determined by RT-PCR and Western bloting,respectively.Results:The expression of CXCR4 was similar in both SKBR3 and MCF-7(P0.05),but the expression of HER-2 was statistically different(P0.01);NT21MP could downregulate the expression of CXCR4 in MCF-7 and SKBR3 cells dramatically,but the difference exists in the different cells(P0.01).Conclusions:NT21MP can downregulate the expressions of CXCR4 in MCF-7 and SKBR3 with different degree." @default.
- W2364758432 created "2016-06-24" @default.
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- W2364758432 date "2009-01-01" @default.
- W2364758432 modified "2023-09-23" @default.
- W2364758432 title "Influence of inhibitory polypeptide for CXCR4 on the expression of CXCR4 in the different strains of breast carcinoma cells" @default.
- W2364758432 hasPublicationYear "2009" @default.
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