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- W2364760140 abstract "Objective To explore the mechanisms of heme oxygenase 1 (HO 1) and endogenous CO and the relationship between them in asthma Methods Guinea pig models of asthma were applied, some of them were treated with dexamethasone. Levels of HO 1 activity, COHb and cGMP in serum or lung tissue were determined by using spectrophotometry etc Results In acute asthmatic group, COHb in blood was (9 2±1 4)%, cGMP (1 59±0 30) pmol/mg and HO 1 activity was (113 2±17 7) nmol/(L·h) in serum and (55 5± 5 6) nmol/(mg·h) in lung These parameters significantly increased as compared with normal control group and dexamethasone treated group ( t =11 51～22 47, P 0 01) However, all the above parameters except for cGMP of dexamethasone treated group were higher than those of normal controls ( P 0 01) HO 1 activities in serum and lung tissue were positively correlated with each other or with the COHb and cGMP ( r =0 86～0 97, P 0 01) Conclusion In asthma, the increased HO 1 activity resulted in increase of endogenous CO that can enhance cGMP" @default.
- W2364760140 created "2016-06-24" @default.
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- W2364760140 date "1999-01-01" @default.
- W2364760140 modified "2023-09-25" @default.
- W2364760140 title "Relationship between heme oxygenase 1 and endogenous CO in asthma model of guinea pigs" @default.
- W2364760140 hasPublicationYear "1999" @default.
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