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- W2364761821 abstract "Objective To investigate the effects of irbesartan on Ica-L, IK1 , INa and action potentials in rabbit ventricular mvocytes. Metfaods Membrane currents and action potentials were recorded with patch electrodes in a whole-cell clamp configuration. Results (1)Irbesartan (10,100,1000 nM)reduced the ICa-L(pA/pF)from - 9.8 ± 1.1 (con-trol)to -6.7±0.9, -4.2±0.8 and -2.1± 0.4 ( n = 6, P 0.05 or 0.01)in a concentration-dependent manner. (2)Irbesartan upshifted the current-voltage (I-V)curve, but the activation voltage, the maximal activation voltage and reversai potential of ICa-L were not significantly altered by irbesartan. (3) Irbesartan blocked ICa-L in a use-dependent manner. (4)Activation curve of Ica-L was not affected markedly.Irbesartan (100nM)markedly shifted the steady-state in-activation curve of ICa-L to the left, and accelerated the voltage-dependent inactivation of calcium current, V1/2 value was ( - 30 ±5)mV in the control and ( - 39 ± 6)mV in the presence of irbesartan, the K value was (8.2 ± 0.7)and (11.6± 1 .3)respectively ( n = 5, P 0.05) . (5)Irbesartan markedly delayed the time constant (τ)of reactivation of L-type Ca2+ channel from (62.5 ±2.3)ms to (126.4 ± 2.6)ms ( P 0.01) . (6)Irbesartan had no effects on IK1 and INa. (7)APE30, APD50,, and APD90 were shortened from (106.0± 10.5)ms, (125.0± 16.4)ms, (178.0 ± 23.5)ms to (82.0±15.6)ms, (99.0±6.3)ms, (122.0±18.0)ms (n = 5, P0.05)following administration of irbesartan 100 nM, but the rest membrane potential and amplitude of AP were not changed significantly. Condusion Irbesartan in-hibits ICa-L and mainly acts on the inactivated state of L-type caicium channel." @default.
- W2364761821 created "2016-06-24" @default.
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- W2364761821 date "2003-01-01" @default.
- W2364761821 modified "2023-09-27" @default.
- W2364761821 title "Effect of irbesartan on L-type calcium channel current in rabbit ventricular myocytes" @default.
- W2364761821 hasPublicationYear "2003" @default.
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