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- W2364762537 abstract "Objective To explore the associations between ITGA3,TP53INP2,and AXIN2gene polymorphisms and papillary thyroid carcinoma(PTC),and to provide basis for the prevention and treatment of PTC. Methods 56cases of blood samples from PTC patients(case group)and 50cases of normal blood samples fromnormal thyroid persons(control group)were collected.The genotypes of 14SNPs of ITGA3,TP53INP2,and AXIN2genes were detected by matrix-assisted laser desorption ionization time of flight mass spectrometry.The differences of genotypic and allelic frequencies of different sites between case and control groups were detected;the relationship between haplotype consisted of two or more sites and PTC was analyzed by UNPHASED3.1.4 software.Results The Hardy-Weinberg equilibrium results showed that the genotypic frequency distribution of 14sites in two groups were in accordance with Hardy-Weinberg equilibrium(P0.05).The distribution of allelic frequencies of rs11655966,rs3923086,and rs7591sites in AXIN2gene were statistically different between two groups(χ2=6.029,df=1,P=0.014;χ2=4.518,df=1,P=0.034;χ2=4.674,df=1,P=0.031).The distribution of allelic frequency of rs910870site in TP53INP2gene was statistically different between two groups(χ2=4.583,df=1,P=0.032).The distribution of allelic and genotypic frequency of five tag SNPs in ITGA3 gene were not statistically different between two groups(P0.05).The combined analysis of multiple sites results showed that there were statistically differences in the distribution of rs7210356-rs7591-rs4074947-rs11655966-rs3923086-rs4791169-rs2240308haplo-system between two groups(P0.05).Conclusion The rs11655966, rs3923086,and rs7591sites in AXIN2gene and rs910870site in TP53INP2gene might be associated with PTC. The haplotype consisted of multiple sites in AXIN2gene might be associated with PTC.ITGA3 might not be associated with PTC." @default.
- W2364762537 created "2016-06-24" @default.
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- W2364762537 date "2014-01-01" @default.
- W2364762537 modified "2023-09-22" @default.
- W2364762537 title "Association between ITGA3,TP53INP2,and AXIN2 gene polymorphism and papillary thyroid carcinoma" @default.
- W2364762537 hasPublicationYear "2014" @default.
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