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• W2364762990 abstract "The effects of fleroxacin and other new 4-quinolones on cellular functions and topoisomerase II of HeLa cells were investigated. The potency of cytotoxicity increased in the order fleroxacin < nalidixic acid < ofloxacin < norfloxacin < ciprofloxacin. The cytotoxicity was well correlated with inhibitory effects of 4-quinolones on topoisomerase II. However, the cytotoxicity did not correlate with antibacterial activity, and cytotoxicity was observed only at greater than 100-fold higher concentrations than the minimum inhibitory concentrations of new 4-quinolones for Enterobacteriaceae. Judging from the serum levels attainable after oral administration, new 4-quinolones, especially fleroxacin, will have little effect on topoisomerase in eukaryotic cells." @default.
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• W2364762990 date "1988-10-01" @default.
• W2364762990 modified "2023-10-17" @default.
• W2364762990 title "Effects of fleroxacin on HeLa cell functions functions and topoisomerase II" @default.
• W2364762990 doi "https://doi.org/10.1093/jac/22.supplement_d.91" @default.
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