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- W2364763776 abstract "Objective:To develop an RP-HPLC model in vitro for screening 5α-reductase inhibitors.Methods: The 5α-reductase was abstracted from the liver of rat.The activity of reductase was determined by the change in testosterone concentration using RP-HPLC.The chromatographic conditions were:column,Diamonsil~(TM)C_(18)(250 mm×4.6 mm,5 μm);mobile phase,methanol-water-acetic acid(70:29.5:0.5).flow rate,1.0 mL·min~(-1); column temperature,30 ℃;detection wavelength,230 nm.Results:Testosterone was effectively separated from other component under the chromatographic conditions.Epristeride,one effective 5α-reductase inhibitor,inhibited the activity of 5α-reductase in a dose-dependent manner.Conclusion:The method is simple,accurate and suitable for screening of 5α-reductase inhibitor in vitro." @default.
- W2364763776 created "2016-06-24" @default.
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- W2364763776 date "2008-01-01" @default.
- W2364763776 modified "2023-09-25" @default.
- W2364763776 title "A model to screen 5α-reductase inhibitors in vitro by RP-HPLC" @default.
- W2364763776 hasPublicationYear "2008" @default.
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