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- W2364765827 abstract "AIM To establish an animal model for acute and chronic sinusitis in rabbits and to observe their mucosa and mucociliary change. METHODS Experimental sinusitis was induced in rabbits by blocking the osmium and occluding withcotton packs and inoculating 10 11 cfu streptococcus pneumoniae in 0.4 mL. The animals were examined histologically and bacteriologically after 5 and 35 days. RESULTS The actue model produced a sinus infection that was characterized by exudates of neutrophils and eosinophils, mucosal infiltration with lymphocytes and plasma cells, and epithelial degeneration. The infected sinuses of chronic model displayed signs of moderate or severe inflammation throughout the study period. Ciliary damage and desquamation, hyperplasia and metaplasia of the epithelium were characteristic features. Furthermore, heavy leukocyte cell infiltration, fibrosis, periosteal hyperplasia and bone degradation and formation were also frequently encountered. There was a 100% correlation rate between culture of specimen obitain from the maxillary sinus in all 16 animal of AS group and CS group. Normal animals showed no bacterial growth from the maxillary sinus. CONCLUSION Stable acute and chronic sinusitis model can be established by using the method mentioned above." @default.
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- W2364765827 date "2001-01-01" @default.
- W2364765827 modified "2023-09-24" @default.
- W2364765827 title "Experimental sinusitis induced by Streptococcus pneuminoae in rabbits" @default.
- W2364765827 hasPublicationYear "2001" @default.
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