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- W2364767536 abstract "Objective To evaluate the effects of Tongxinluo on the structure of resistance vessels in Spontaneously Hypertensive Rats(SHR). Methods Thirty twelve-week-old male SHRs were divided into three groups at random: untreated control(n=10), low-dose(0.5 g/kg·d, n=10), high-dose(1.5 g/kg·d , n=10) Tongxinlou treatment. Tongxinluo, a Chinese herbal compound, were given by gavage for 12 weeks, while SHR control group and 10 age and sex-matched Wistar Kyoto rats (WKY) were given tap water. Systolic blood pressure (SBP) and heart rate (HR) were measured using tail-cuff technique. Wall to lumen area ratio (W/L) of mesenteric artery (3rd grade branch) were assessed by morphormetic assay. Vascular reactivity to vasoactive substance were recorded using mesenteric artery rings. Results After 12 weeks treatment, SBP in untreated group is significantly lower both in high and low-dose group than in control group (P0.05). The W/L of mesenteric artery was markedly reduced in the high dose groups than in the control ( P0.05).Conclusion Tongxinluo may attenuate vascular hypertrophy in SHR, enhanced vascular sensitivity to vasodilators and attenuate the sensitivity to vasoconstrictors." @default.
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- W2364767536 date "2006-01-01" @default.
- W2364767536 modified "2023-09-24" @default.
- W2364767536 title "Effects of Tongxinluo on Structure and funetion of Resistance Vessels in Spontaneously Hypertensive Rats" @default.
- W2364767536 hasPublicationYear "2006" @default.
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