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- W2364773350 abstract "Purpose To investigate the clinicopathologic characteristics,diagnosis,differential diagnosis and treatment of primary malignant melanoma of esophagus( PMME). Methods Using light microscopy and immunohistochemistry,we studied 5 cases of PMME,reviewed relevant literature and analyzed the clinical manifestations,radiographic,histological,immunohistochemical characteristics,treatment and prognosis of the tumor. Results The 5 male patients,at the mean age of 63. 4 years,all presented dysphagia and the symptoms were progressively aggravated. Histopathologically,the tumor cells were arranged in nests or cords and /or flake structures,round or polygonal in shape,with abundant pink cytoplasm,and melanin granules were visible within the cytoplasm. The nucleus varied in size,centrally or eccentrically located,with prominent nucleoli,and frequent pathological mitosis. Immunohistochemical staining showed that the tumor cells were positive for HMB-45,Melan-A,S-100,but negative for CK. Ki-67 index was 40%-45%. Conclusions Primary malignant melanoma of the esophagus is very rare and highly malignant,with poor prognosis. Immunohistochemical staining helps its diagnosis and differential diagnosis from other tumors including poorly-differentiated cancer,carcinosarooma,esophageal lymphoma,neuroendocrine carcinoma and leiomyoma of the esophagus." @default.
- W2364773350 created "2016-06-24" @default.
- W2364773350 creator A5047424964 @default.
- W2364773350 date "2014-01-01" @default.
- W2364773350 modified "2023-09-24" @default.
- W2364773350 title "Primary malignant melanoma of the esophagus:a clinicopathological study of 5 cases" @default.
- W2364773350 hasPublicationYear "2014" @default.
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