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- W2364773352 abstract "Objective Nowadays the implantation of 125I radioactive seeds into pancreatic cancer is considered to be an effective way to diminish the volume of neoplasm and reduce the pain.This experiment aims to investigate the effects of continuous 125I seeds irradiation in vitro on the proliferation,DNA synthesis,cell cycle and apoptosis of sw1990 and panc-1 cells of pancreas cancer,so as to provide a useful reference for the selection of experimental cells in doing radiation research of pancreas cancer.Methods Sw1990 and Panc-1 cells in exponential growth were irradiated at an initial dose rate of 12.13 cGy/h in vitro and were kept under exposure until the total dose reached 0,2,4,6 and 8 Gy separately.After irradiation,the cells were collected.The proliferation of cells after irradiation was evaluated by counting the number of colonies and the cell survival curves were plotted,with which the cell survival rate(SF2) was calculated.The apoptosis of cell,cell cycle and DNA synthesis after the 3H-TDR incorporation experiment were determined.Results The SF2 of SW1990 cells was 0.766 ± 0.063,while the SF2 of Panc-1 cells was 0.729 ± 0.045.As the dose increasing,the ratio of 3H-TDR incorporation experiment decreased.The highest rate of apoptosis of Sw1990 cells appeared at 8 Gy,while that of Panc-1 cells appeared at 6 Gy.With the dose increasing,the percentage of G2/M cell cycle arrest increased.Conclusion In continuous 125I seeds irradiation on sw1990 and panc-1 cells in vitro the major mechanisms of the inhibition of cell proliferation are the apoptosis and the G2/ M cell cycle arrest.At the dosage of 0,2,4,6 and 8 Gy the biological effects on the Sw1990 cells and on the Panc-1 cells are of no statistically significant difference." @default.
- W2364773352 created "2016-06-24" @default.
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- W2364773352 date "2013-01-01" @default.
- W2364773352 modified "2023-09-23" @default.
- W2364773352 title "The biological effects of continuous ~(125)I seeds irradiation on sw1990 and panc-1 cells: a comparison study" @default.
- W2364773352 hasPublicationYear "2013" @default.
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