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- W2364776064 abstract "Objective To study the effects of human kallikrein gene delivery into hypertensive rats.Methods Human kallikrein gene was amplified from the plasmid and sub-cloned into plasmid pcDNA3.1 and the.recombinant plasmid was sequenced.Hypertension was induced by addition of 10% fructose to drinking water using Wistar rats.And then the recombinant plasmid and empty plasmid was delivered by intravenous injection.The level of the kallikrein in rat serum was assayed by ELISA.The systolic blood pressure was measured by the tail cuff method twice a week.Insulin,serum glucose and triglyceride were also detected.Results Compared with the control group,a single injection of human tissue kallikrein DNA caused reduction of systolic pressure clearly with the obviously increasing of kallikrein protein level.Conclusion Gene delivery of human tissue kallikrein could reduce hypertension in fructose-fed rats." @default.
- W2364776064 created "2016-06-24" @default.
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- W2364776064 date "2006-01-01" @default.
- W2364776064 modified "2023-09-27" @default.
- W2364776064 title "Effects of gene delivery of human tissue kallikrein into hypertensive hats" @default.
- W2364776064 hasPublicationYear "2006" @default.
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