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- W2364777664 abstract "Objective To observe the influence of metformin on the expression of AMPK and GluT4 in 3T3-L1 adipocyte with insulin resistance. Methods 3T3-L1 preadipocytes were induced to differentiate into mature adipocytes and to be proved by oil red O stain.The model cells with insulin resistant were established by dexamethasone.Then the change of residual glucose concentration in cell culture medium was measurd by the glucose oxidase method.After drug intervention by metformin,the residual glucose concentration in cell culture medium was determined and the cells mRNA levels of AMPK and GluT4 were detected by real-time fluorescent quantitation PCR. Results After treating with different concentrations of metformin in drug intervention groups,residual glucose concentration in the cell culture medium was significantly lower than model group(P0.01);the mRNA levels of AMPK and GluT4in drug intervention groups were significantly increased(P0.01). Conclusion Metformin increases the expression of the mRNA levels of AMPK and GluT4in 3T3-L1adipocyte with insulin resistance,and increases glucose utilization of the cell." @default.
- W2364777664 created "2016-06-24" @default.
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- W2364777664 date "2014-01-01" @default.
- W2364777664 modified "2023-09-22" @default.
- W2364777664 title "Influence of metformin on the expression of adenosine monophosphate-activated protein kinase(AMPK)and glucose transporter type 4(GluT4)in 3T3-L1adipocyte with insulin resistance" @default.
- W2364777664 hasPublicationYear "2014" @default.
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