Matches in SemOpenAlex for { <https://semopenalex.org/work/W2364777777> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2364777777 abstract "Objective:To investigate relationships of expression levels of EGFR,p-EGFR and p-IGFR-1β in colorectal cancer cell lines with their sensitivities to gefitinib,and assess relationships of the expression in specimen tissues with clinicopathological parameters of colorectal cancer patients.Methods:The levels of EGFR,p-EGFR and p-IGFR-1β expression were determined with western blot analysis after gross protein was extracted.Band gray scale scan was performed to evaluate the relative value of protein expression.Results:EGFR or p-EGFR was expressed highest in Lovo cells,lowest in SW620 cells(P0.05),and no differences among the other cell lines.p-IGFR-1β was undetectable or expressed at very low levels in the most and moderate gefitinib-sensitive cell lines(Lovo,HT29 and SW480) and was seemingly much lower in the most sensitive cell line(Lovo) than in the moderate ones(HT29 and SW480) and however,expressed at strikingly high levels in all resistant cell lines(HCT116,LS174T and SW620).55.6%(10/18) colorectal cancer specimens had higher levels of EGFR expression than 37.5%(3/18) did in normal tissue specimens from the same patients.33.3%(6/18) tumor tissue had significant higher levels of p-EGFR than 5.6%(1/18) did in normal tissue(P0.05).44.4%(8/18) tumor tissue had significant higher levels of p-IGFR-1β than 11.1%(2/18) did in normal tissue(P0.05).The expression of EGFR,p-EGFR and p-IGFR-1β had no correlation with each other.EGFR or p-EGFR expression did not show any association with the clinicopathological parameters,while p-IGFR-1β expression was significantly increased in patients with lymph node metastasis(P0.05),and there was a same trend in patients with advanced stage.Conclusion:With our previous study,it is suggested that the colorectal cancer cells were best sensitive to gefitinib,which expressed high p-EGFR and low p-IGFR-1β.The expression of p-EGFR and p-IGFR-1β were both significantly increased in colorectal cancer tissue and were independent from each other,and increased p-IGFR-1β expression may favor the metastasis of colorectal cancer." @default.
- W2364777777 created "2016-06-24" @default.
- W2364777777 creator A5027922054 @default.
- W2364777777 date "2009-01-01" @default.
- W2364777777 modified "2023-09-27" @default.
- W2364777777 title "Expression and Significance of EGFR,p-EGFR and p-IGFR-1β in Human Colorectal Cancer Cell Lines and Specimen Tissues" @default.
- W2364777777 hasPublicationYear "2009" @default.
- W2364777777 type Work @default.
- W2364777777 sameAs 2364777777 @default.
- W2364777777 citedByCount "0" @default.
- W2364777777 crossrefType "journal-article" @default.
- W2364777777 hasAuthorship W2364777777A5027922054 @default.
- W2364777777 hasConcept C104317684 @default.
- W2364777777 hasConcept C121608353 @default.
- W2364777777 hasConcept C126322002 @default.
- W2364777777 hasConcept C142724271 @default.
- W2364777777 hasConcept C144174609 @default.
- W2364777777 hasConcept C170493617 @default.
- W2364777777 hasConcept C2775960820 @default.
- W2364777777 hasConcept C2776415932 @default.
- W2364777777 hasConcept C2779438470 @default.
- W2364777777 hasConcept C2780580887 @default.
- W2364777777 hasConcept C502942594 @default.
- W2364777777 hasConcept C526805850 @default.
- W2364777777 hasConcept C54355233 @default.
- W2364777777 hasConcept C55493867 @default.
- W2364777777 hasConcept C71924100 @default.
- W2364777777 hasConcept C81885089 @default.
- W2364777777 hasConcept C86803240 @default.
- W2364777777 hasConceptScore W2364777777C104317684 @default.
- W2364777777 hasConceptScore W2364777777C121608353 @default.
- W2364777777 hasConceptScore W2364777777C126322002 @default.
- W2364777777 hasConceptScore W2364777777C142724271 @default.
- W2364777777 hasConceptScore W2364777777C144174609 @default.
- W2364777777 hasConceptScore W2364777777C170493617 @default.
- W2364777777 hasConceptScore W2364777777C2775960820 @default.
- W2364777777 hasConceptScore W2364777777C2776415932 @default.
- W2364777777 hasConceptScore W2364777777C2779438470 @default.
- W2364777777 hasConceptScore W2364777777C2780580887 @default.
- W2364777777 hasConceptScore W2364777777C502942594 @default.
- W2364777777 hasConceptScore W2364777777C526805850 @default.
- W2364777777 hasConceptScore W2364777777C54355233 @default.
- W2364777777 hasConceptScore W2364777777C55493867 @default.
- W2364777777 hasConceptScore W2364777777C71924100 @default.
- W2364777777 hasConceptScore W2364777777C81885089 @default.
- W2364777777 hasConceptScore W2364777777C86803240 @default.
- W2364777777 hasLocation W23647777771 @default.
- W2364777777 hasOpenAccess W2364777777 @default.
- W2364777777 hasPrimaryLocation W23647777771 @default.
- W2364777777 hasRelatedWork W2023095319 @default.
- W2364777777 hasRelatedWork W2120708338 @default.
- W2364777777 hasRelatedWork W2331071950 @default.
- W2364777777 hasRelatedWork W2358399807 @default.
- W2364777777 hasRelatedWork W2375581209 @default.
- W2364777777 hasRelatedWork W2378704451 @default.
- W2364777777 hasRelatedWork W2407385193 @default.
- W2364777777 hasRelatedWork W2441083230 @default.
- W2364777777 hasRelatedWork W2593259217 @default.
- W2364777777 hasRelatedWork W2603465511 @default.
- W2364777777 hasRelatedWork W2726613550 @default.
- W2364777777 hasRelatedWork W2810381907 @default.
- W2364777777 hasRelatedWork W3000056783 @default.
- W2364777777 hasRelatedWork W3000070812 @default.
- W2364777777 hasRelatedWork W3028829742 @default.
- W2364777777 hasRelatedWork W3028849623 @default.
- W2364777777 hasRelatedWork W3031050661 @default.
- W2364777777 hasRelatedWork W3142541024 @default.
- W2364777777 hasRelatedWork W3204996649 @default.
- W2364777777 hasRelatedWork W2515199452 @default.
- W2364777777 isParatext "false" @default.
- W2364777777 isRetracted "false" @default.
- W2364777777 magId "2364777777" @default.
- W2364777777 workType "article" @default.