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- W2364780917 abstract "Objective:To observe the effect of praziquanteland and interferon-γ on liver sinusoid of mice infected by schistosoma japonicum. Methods:The mice were divided randomly into three groups after infection at 16 week:infection group, praziquantel treated alone group and the combination of praziquantel and interferon-γ treated group. The infected mice were treated for 8 weeks and 10 normal mice were as the control. The liver specimens of mice were used for pathological examination to get to know the degree of liver fibrois by semi-quantify and observe the expression of C-Ⅳ and vWF in liver sinusoid by immuhistochemisty staining. The ultramicrostructure of the liver tissue was observed by transmission electron microscope.Results:After chemotherapy with praziquantel, the fenestration in SEC could not be observed, the base membrane could be observed, the liver fibrosis degree, the expression of C-Ⅳ and vWF in liver sinusoid remained consisitent with infection group (P0.05). When treated with praziquantel and interferon-γ, the fenestration in SEC could be observed, but the base membrane could not be observed, the liver fibrosis degree, the expression of C-Ⅳ and vWF in liver sinusoid decreased obviously (P0.05 or P0.01). Conclusion:Interferon-γ can reverse pathological changes in liver sinusoid induced by schistosoma japoncium, and it's anti-fibrotic effect may depend on this." @default.
- W2364780917 created "2016-06-24" @default.
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- W2364780917 date "2006-01-01" @default.
- W2364780917 modified "2023-09-24" @default.
- W2364780917 title "Effect of chemotherapy and anti-fibrosis on liver sinusoid of mice infected by schistosoma japoncium" @default.
- W2364780917 hasPublicationYear "2006" @default.
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