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- W2364784544 abstract "Background WNK1 is a recently found upstream kinase of multiple transporters and channels in kidney,while might be involved in the biological effect of aldosterone.Objective To investigate the effect of in- creases in aldosterone induced by high dietary potassium intake on the expression of rat kidney WNK1 isoforms. Methods High KCl solution(0.5 mol/L)in diet was administrated to Wistar rats(n=8).The concentrations of e- lectrolytes and aldosterone in serum as well as 24 hour electrolytes concentrations in urine were measured.RT-PCR was used to detected the expression of rat kidney WNK1 isoforms.Results Serum concentrations of aldosterone in high K+diet rats was 7.4 times of that in the control group(1.86±0.66 vs control:0.25+0.04 μg/L,P0.01). Serum K~+and urine K~+and Cl~-in the experimental rats were significant higher than those in normal rats while the urine Na+was lower(P0.05).There were no significant difference of serum Na~+or Cl~-between two groups(P 0.05).The expression of WNK1-KS is higher in the experimental rats than that in control rats(1.60±0.22 vs 0.38±0.08,P0.01)while no differences was found in the expression of WNK1-Lin both groups(0.27±0.07 vs 0.26±0.07,P0.05).Conclusion The high dietary potassium intake induces the secretion of aldosterone.Al- dosterone regulating serum and urine sodium and potassium is associated with upregulated expression of WNK1-KS." @default.
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- W2364784544 date "2008-01-01" @default.
- W2364784544 modified "2023-09-25" @default.
- W2364784544 title "The Effect of High Dietary Potassium Intake on the Expression of WNK1 Isoforms in Rat Kidney" @default.
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