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- W2364789228 abstract "Objective: To study the change of 1HMRS in first-episode and neuroleptic-naive patients with schizophrenia.Methods:26 patients and 12 healthy controls were selected to perform MRI and 1HMRS examination. Point resolved spectroscopy sequence(TR 2000msec, TE 135msec) was required for 1HMRS. The metabolites in the spectra includes N-acetylaspartate(NAA)?choline compounds(Cho)?creatine compounds(Cr)?myo-inositol(MI)?Lactate(Lac)?glutamate and glutamine(Glu-Gln).Results:A decrease of NAA/CR and NAA/Cho has been shown in both the dorsolateral prefrontal cortex and the hippocampus of schizophrenic patients; moreover NAA/Cr of dorsolateral prefrontal cortex are closely related with the total negative syndromes scales of BPRS; However, there are no statistically significant differences in metabolite levels in thalamus?temporal lobes and occipital lobe between patients and controls.Conclusion:There is significant difference of manifestation of 1HMRS between schizophrenic patients and normal persons,which supports the brain dysfunction in schizophrenia." @default.
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- W2364789228 date "2006-01-01" @default.
- W2364789228 modified "2023-09-23" @default.
- W2364789228 title "Proton Magnetic Resonance Spectroscopy of Brains in First-episode Schizophrenic Patients" @default.
- W2364789228 hasPublicationYear "2006" @default.
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