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- W2364790129 abstract "Recent studies suggest uric acid(UA) have contribution in renal interstitial fibrosis. This study aimed to observe whether uric acid promote oxidative stress and change TGF-β expression in renal tubular epithelia cell,and investigate the underlying mechanism. Firstly, HK-2 cells were cultured in UA(240, 480, 720 μmol/L) for 48 h.Then the expression levels of TGF-β and prohibitin(PHB) were examined by Western blot and immunofluorescence cytochemistry, respectively; the mitochondrial ROS production was detected by MitoSOX staining; the malondialdehyde(MDA) content and total superoxide dismutase(T-SOD) activity in the supernatants were measured by spectrophotometer. Our results revealed that UA treatment upregulated TGF-β expression but down-regulated PHB expression of HK-2 cells in a dose dependent manner(480-720 μmol/L). Furthermore, mitochondrial ROS production was elevated in cells cultured with UA(480-720 μmol/L) for 48 h. In parallel with the changes of ROS generation, the MDA content increased but T-SOD activity decreased in the supernatants of HK-2 cells exposed to UA. Taken together, our results demonstrated that UA can induce oxidative stress and enhance TGF-β expression in HK-2 cells through suppressing PHB expression and increasing the mitochondrial ROS production." @default.
- W2364790129 created "2016-06-24" @default.
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- W2364790129 date "2014-01-01" @default.
- W2364790129 modified "2023-09-23" @default.
- W2364790129 title "Effects of uric acid on oxidative stress and TGF-β expression of human renal tubular epithelia cell" @default.
- W2364790129 hasPublicationYear "2014" @default.
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