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- W2364790151 abstract "[Objective] To investigate the role of CD 134 (OX40) and NF-KB in the pathogenesis of lupus nephritis (LN). [Methods] Renal in situ CD 134 and NF-KB expression were examined in 40 LN patientbiopsy specimens by immunohistochemistry and microwave-based immunohistochemistry respectively. The relationship between expression of CD134 and NF-KB was analyzed. [Results] In class IV and non-class IV LN patients, the expression of glomerular , tubular and renal interstitial CD134( gray level ) were 4. 22 ±1.65, 2. 43 ±1.32, 7. 72 ±2. 69,4.46± 2. 41 and 6. 56 ± 2. 17,4. 05 ± 1. 83. It was higher than that of normal control, P 0. 01, P 0. 05 respectively. The expression of NF-KB in class IV and non-class IV LN patients were 13. 1±8. 2 NF-KB positive glomerular cell/ gcs, 38.5%±17.2% NF-KB positive tubular and 3. 2 ±1.8 NF-KB positive glomerular cell/ gcs, 22. 1% ± 9. 8% NF-KB positive tubular. It was also higher than that of normal control, all P 0. 05 . The expressiom of it in class IV LN was higher than that of non-class IV LN group ( P 0. 05), where there was intense staining of endothelial cell, distal tubules, and interstitial mononuclear cell. The CD134 expression of glomerular and tubular was closely related to NF-KB expression respectively ( r = 0. 554 2, P 0. 05; r = 0. 627 9, P 0. 05). [Conclusion] The abnormal expression of costimulato-ry molecule CD134 is well evidenced in LN. Strong expression of renal in situ NF-KB is likely mediat- ed by CD 134 signal pathway mediate activation." @default.
- W2364790151 created "2016-06-24" @default.
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- W2364790151 date "2003-01-01" @default.
- W2364790151 modified "2023-09-23" @default.
- W2364790151 title "Expression and Role of CD134 and NF-KB in Renal Tissue of Lupus Nephritis" @default.
- W2364790151 hasPublicationYear "2003" @default.
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