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- W2364792452 abstract "Objective To prepare Pluronic lecithin organogel(PLO),evaluate its in vitro properties and investigate the tissue distribution with piroxicamn as the model drug.Methods The rheological parameters of PLO were obtained by cone-plate configuration rheometer,the in vitro release drug and transdermal permeability were tested by Franz cell method,and the pharmacokinetics and local tissues distribution were investigated after topical application of piroxicam PLO to rat skin.Results It was demonstrated that PLO had typical rheological property.Percents of in vitro released drug and permeated through rat full-skin were(81.56±3.09)% and(3.80±1.59)%,respectively.The drug concentration-time profiles of skin and muscle showed two peaks,and ρmax and AUC of various local tissues of applied side were higher than that of plasma and tissues of contralateral side which might be attributed to systemic redistribution and direct penetration.Conclusions PLO can be a potential carrier of piroxicam or other active drugs for topical administration." @default.
- W2364792452 created "2016-06-24" @default.
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- W2364792452 date "2009-01-01" @default.
- W2364792452 modified "2023-09-22" @default.
- W2364792452 title "In vitro evaluation and local tissue distribution of piroxicam Pluronic lecithin organogel" @default.
- W2364792452 hasPublicationYear "2009" @default.
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