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- W2364793069 abstract "AIM: To explore the effect of peroxynitrite anion (ONOO- ) on development of hepatic fibrosis. METHODS: The hepatic fibrosis (HF) of Wistar rats was established by giving complex pathogens. The rats were intra - gastrically infused with 0.9% salt (1.5 mL/d) and inhibitor of nitric oxide synthase (NOS) , L- NNA (20 mg·kg-1·d-1), respectively. At the end of the 4th week, the levels of plasma LPS and NO2- /NO3- were detected. The expression of nitrotyrosine (NT) in hepatic tissue was examined by immunohistochemical techniques. The degree of hepatic fibrosis was observed by VG staining. RESULTS: The level of plasma NO in HF + NNA group was remarkably lower than that in HF group ( P 0.01). The expression of NT in hepatic tissue was the strongest and the degree of hepatic fibrosis was the most serious in HF group. CONCLUSION: ONOO- promotes the development of hepatic fibrosis." @default.
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- W2364793069 date "2005-01-01" @default.
- W2364793069 modified "2023-09-23" @default.
- W2364793069 title "Effect of peroxynitrite anion (ONOO- ) on the development of hepatic fibrosis" @default.
- W2364793069 hasPublicationYear "2005" @default.
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