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- W2364793635 abstract "2-[4-(4-Hydroxylbenzyl) piperazin-1-ylmethyl]pyrazolo[1,5-α]pyridine is synthesized from pyrazolo[1,5-α]pyridine-2-carbaldehyde,l-piperazinearboxaldehyde and 4-hydroxylbenzaldehyde through a three-step procedure.The structures of the intermediates and the target compound are confirmed by 1H NMR and ESI MS.Through vitro activity assay,the affinity constants of the target compound are determined to be 4200,2590,2.2 nM for D_2,D_3,D_4 receptor respectively.It suggests that 2-[4-(4-hydroxylbenzyl)piperazin-1-ylmethyl]pyrazolo[1,5-α]pyridine is a potential dopamine D_4 receptor ligand." @default.
- W2364793635 created "2016-06-24" @default.
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- W2364793635 date "2014-01-01" @default.
- W2364793635 modified "2023-09-24" @default.
- W2364793635 title "Synthesis of 2-[4-(4-hydroxylbenzyl)piperazin-1-ylmethyl] Pyrazolo [1,5-α]Pyridine and Activity Assay" @default.
- W2364793635 hasPublicationYear "2014" @default.
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