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- W2364793739 abstract "OBJECTIVE To develop a qualitative analylic method for detecting Adefovir monopivoxil in Adefovir dipivoxil drug substance and its tablets.METHODS HPLC-DAD and HPLC-ToF/MS methods were used to compare the retention time,UV,MS of Adefovir monopivoxil reference substance and the corresponding peaks in Adefovir dipivoxil drug substance and its tablets,and exhibit same retention time.The quailty precision and isotopic ratio of the samples were calculated.RESULTS The analyte and reference substance can be separated and the ultraviolet spectra of Adefovir monopivoxil reference substance and samples were consistent between 200-400 nm.And the max absorption wave was 260 nm.The mass chromatograms and isotopic ratio of reference substance and the analyte were uniform.CONCLUSION This method is accurate,sensitive.It is a applicable qualitative method for the detection of the related substance in Adefovir dipivoxil raw materials and tablets." @default.
- W2364793739 created "2016-06-24" @default.
- W2364793739 creator A5083772534 @default.
- W2364793739 date "2009-01-01" @default.
- W2364793739 modified "2023-09-25" @default.
- W2364793739 title "Determination of Adefovir monopivoxil in Adefovir dipivoxil drug substance and its tablets by HPLC-DAD and HPLC-ToF/MS" @default.
- W2364793739 hasPublicationYear "2009" @default.
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