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- W2364794744 abstract "Objective: To Study the effects and mechanisms of systemic 5-HT administration on sleep-wakefulness cycle by microinjection into nucleus of solitarius tracts (NST) in rats. Methods: Male SD rats were divided into seven groups and were given 5-hydroxytryptophan (5-HTP), 5-HTR antagonist methysergide (MS), 5-HT1AR agonist 8-OH-DPAT, 5-HT1AR antagonist spiperone, cAMP, PKA antagonist H89 and normal saline (NS) separately by microinjection into the nucleus of solitarius tract. The electroencephalogram(EEG) and electromyogram (EMG) were recorded by a NIHON KOHOEN polygragh instrument. The ABC immunohistochemical method was used to detect 5-HT1AR positive neurons and 5-HT expression in NST of rats. Results: Compare with pre -administration, there were no significant change in sleep -wakefulness cycle after administration in NS group and MS group. There were a significant decline of waking period and an increase of paradoxical sleep(PS) in 5-HTP group, 8-OH-DPAT group and H89 group (P 0.05 or P 0.01). There were also a significant increase of the slow wave sleep(SWS) in 8-OH-DPAT group and H89 group (P 0.01 or P 0.05). There were significant increase of the waking period (P 0.01 or P 0.05) and decline of SWS (P 0.01 or P 0.05) in the spiperone group and cAMP group, and significant decline of PS in spiperone group (P 0.05). The immunohistochemical results showed that, compared with the NS group, there were more 5-HT1AR positive neurons and more 5-HT expression in serotonergic nerve terminals in 5-HTP group. The reverse results came from MS group. Conclusion: As an inducing area, the important role of NST in the sleep - wakefulness cycle to shorten the waking phase and prolong the sleep phase maybe mediated by the function of 5-HT which binds to 5-HT1AR and decreases the cAMP formation and phosphorylated PKA." @default.
- W2364794744 created "2016-06-24" @default.
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- W2364794744 date "2009-01-01" @default.
- W2364794744 modified "2023-09-23" @default.
- W2364794744 title "Effects and Mechanisms of Systemic 5-HT Microinjections in Nucleus of the Solitary on Sleep-Wakefulness Cycles in Rats" @default.
- W2364794744 hasPublicationYear "2009" @default.
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