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- W2364796812 abstract "AIM: To prepare ethosomes and study on transdermal resorption of tanshinone ethosomes in vitro. METHODS: Tanshinone ethosomes were prepared by thin-film ultrasonic method.The different dosage regimens and volume on the transdermal resorption of tanshinone were evaluated through excised mice skin in vitro using modified Franz-diffustion cells. RESULTS: The mean particle diameter of ethosomes was 79.7 nm,and the encapsulation efficiency was about 81.2%.Cumulative penetration amount of tanshinone from ethosomes was 1024± 104.0 ng/cm2 and skin residual amount was 345.2±58.0 ng/cm2.Cumulative penetration amount increased with ethosomes volume.Liposomes failed to promote the penetration of tanshinone,and its skin residual amount was 625.3 ±124.5 ng/cm2,water-ethanolic suspension also could not promote the penetration of tanshinone,and skin residual amount was 765.0±60.00 ng/cm2. CONCLUSION:Ethosomes can improve significantly the transdermal delivery of tanshinone." @default.
- W2364796812 created "2016-06-24" @default.
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- W2364796812 date "2005-01-01" @default.
- W2364796812 modified "2023-09-27" @default.
- W2364796812 title "Preparation and transdermal resorption of tanshinone ethosomes in vitro" @default.
- W2364796812 hasPublicationYear "2005" @default.
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