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- W2364802004 abstract "Aim To prepare the holoantigens of morphine and morphine-6-succinyl,and to evaluate the antiserum efficacy of both haptens and their effects on the morphine withdrawal symptoms in male mice.Methods Morphine-6-succinyl was prepared by the acid anhydride mixture procedures and,along with morphine,conjugated then with Blue Carrier in the presence of carbodi-imide.After being immunized with both holoantigens and Freud adjuvant,the mice were subjected with antiserum efficacy monitoring(ELISA) and morphine dependence evaluation.Results The antiserum titer to both holoantigens were over 1∶8 000,with a higher titer and a longer maintain period in morphine-6-succinyl immunized mice.There were some significant differences between 2 holoantigen-immunized mice and the control mice on the morphine withdrawal symptoms,such as the body weight reduction,skipping time and latency.The inhibition percentage of both kind of antisera to morphine and morphine-6-auccinyl have reached 50%.Conclusions Both morphine carrier conjugates can elicit a high-titer antibody response and decrease the morphine addiction." @default.
- W2364802004 created "2016-06-24" @default.
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- W2364802004 date "2004-01-01" @default.
- W2364802004 modified "2023-09-25" @default.
- W2364802004 title "The Preparation of Morphine Holoantigens and the Preliminary Evaluation of their Antiserum Efficacy" @default.
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