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- W2364802456 abstract "Objective: To analyze dimension quantity structureactivity relationship (2DQSAR) of 7,9,10 and 11 sites substituted analogues of camptothecin and explore the mechanism of camptothecin analogues inhibitting enzyme. Methods: First preselected the parameters and then modeled the equation using PLS method. Results:BZA correlative equation was obtained and the predictive ability of the resulting equation had been successfully tested by 5 comptothecin analogues. Conclusion: Depending on the QSAR results and SAR conclusions, the interaction pattern between camptothcin analogues and ToPo is better understood and provides a base for the reliable drug design." @default.
- W2364802456 created "2016-06-24" @default.
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- W2364802456 date "1999-01-01" @default.
- W2364802456 modified "2023-09-26" @default.
- W2364802456 title "Dimension quantity structureactivity relationship analysis of 7,9,10 and 11 sites substituted camptothecin analogues" @default.
- W2364802456 hasPublicationYear "1999" @default.
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