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- W2364803784 abstract "Objective To investigate the relationship of p38 mitogen-activated protein kinase(p38) and cardiac ankyrin repeat protein(CARP) with myocardial remodeling in rats with myocardial infarction(MI).Methods MI of rats was induced by ligating anterior descending coronary.Two hours after the induction of MI,the survival rats were randomly assigned to MI group,p38 inhibiter SB203580 group(SB group),and sham operated group(Sham group).Left ventricular weight index(LVWI) and cardiomyocyte cross-sectional area(CSA) in all groups were detected on 1st,7th,28th day.The expressions of p38 and CARP in noninfarcted myocardium were measured by RT-PCR and immunohistochemistry in each group.Results Compared with Sham group,LVWI and CSA increased on 7th and 28th day in MI subgroups(P0.05),the expression of phosphorylated p38(p-p38) elevated in all MI subgroups in all time points(all P0.05);CARP increased on 1st and 7th day(P0.05).Compared with MI group,in SB subgroup,LVWI decreased on 7th day(P0.01),and CSA increased on first day,decreased on 7th and 28th day(P0.01);the expression of p-p38 lowered on the first day(P0.01),and CARP mRNA decreased on 7th day(P0.01).Conclusions p38 and CARP are activated in rats with MI at early time,and subsequently promote myocardial remodeling.The inhibition of p38 leads to the downregrlation of CARP and the improvement of myocardial remodeling." @default.
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- W2364803784 date "2009-01-01" @default.
- W2364803784 modified "2023-09-28" @default.
- W2364803784 title "Relationship between the expressions of p38 and CARP and myocardial remodeling in rats with myocardial infarction" @default.
- W2364803784 hasPublicationYear "2009" @default.
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