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- W2364804304 abstract "AIM:We want to know whether captopril inhibits the activity of neutral endopeptidase (NEP) in airway and increases bronchoconstriction. METHODS:The sensory nervous C fibers of airway in guinea pig could be activated by electrical field stimulation (EFS) or low concentration of capsaicin in vitro , which induce contractions of smooth muscle. Pretreatments with thiorphan and captopril could affect the contractions of airway. RESULTS:The inhibitor of neutral endopeptidase, thiorphan 10 μmol·L -1 , increased the contraction tension of the airway induced by the activation of C fibers. The actions of captopril(3, 10 μmol·L -1 ) are similar to one of thiorphan. Treatments with captopril 10 μmol·L -1 increased tracheal and bronchial contractions by EFS from 16 4±15 4 and 43 7±28 4 to 37 8±20 8 and 58 7±40 1 mg, respectively ( P 0 05). Treatments with captopril increased the tracheal contractions by the low concentration of capsaicin, from 13 3±2 3 to 34 7±9 87 mg ( P 0 01). CONCLUSIONS:These results show that captopril may inhibit the degradation of the neurokinins, inducing the enlargement of contraction tension of airway smooth muscles in guinea pig." @default.
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- W2364804304 date "1997-01-01" @default.
- W2364804304 modified "2023-09-25" @default.
- W2364804304 title "Captopril increases the contractions of guinea pig airway induced by the activation of the nervous C fibers in vitro" @default.
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