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- W2364805268 abstract "Objective To study the reason why TNF-α don't induce hepatocellular carcinoma apoptosis when SMMC-7721 cells were treated with TNF-α alone.Methods Expression of FAK,integrin α 5β 1,E-cadherin and the phosphorylation of FAK was examined in SMMC-7721 cell by Western blot analysis,flow cytometry,immunohistochemistry assay(ABC method).Results TNF-α only slightly decreased E-cadherin and didn't decrease the expression of integrin β 1 subunit,but expression of integrin α 5 subunit showed a significant decrease by TNF-α.We also found that TNF-α increased neither the phosphorylation level of FAK nor its protein level.Conclusion TNF-α doesn't prevent the two message transduction ways with E-cadherin mediated and Intergrin α 5β 1 subuit mediated,it also doesn't start the system of cell apoptosis with caspases mediated.So TNF-α alone doesn't induce cell apoptosis." @default.
- W2364805268 created "2016-06-24" @default.
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- W2364805268 date "2001-01-01" @default.
- W2364805268 modified "2023-09-23" @default.
- W2364805268 title "The Influence on Expression of E-Cadherin,Integrin α_5β_1 Subunit and FAK in Human Hepatocelluar Carcinoma Cell by TNF-α" @default.
- W2364805268 hasPublicationYear "2001" @default.
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