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- W2364809278 abstract "Objective: To study the genetic susceptibility involving the genotypes of HLA-DRB1,DQA1,DQB1 alleies in patients with uterine leiomyoma. Methods The allelic types of HLA-DRB1,DQA1,DQB1 were detected by polymerase chain reaction with sequence-specific primers (PCR-SSP) and polymerase chain reaction-sequence-specific oligonucleotied (PCR-SSO) technique in 51 female patients with utrine leiomyoma at child-bearing age undergoing laparoscopy or surgical operation followed by histological examination. Another 50 healthy and fertile women served as control.Result The frequency of HLA-DRB1 *02, DQA1*0601 in the patient group was markedly higher than that in the control group (P0.05, RR=5.378,15.4), While the frequency of HLA-DRB1*07, *01; DQA1* 0102 in the control group was higher than that in the patient group(P0.05, RR=0.225, 0.375, 0.329). Conclusion The results indicate that HLA-DQA1*0601, *0102; DRB1*02, *01,*07 genes may be correlated with the genetic susceptiblity to uterine leiomyoma." @default.
- W2364809278 created "2016-06-24" @default.
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- W2364809278 date "2001-01-01" @default.
- W2364809278 modified "2023-09-23" @default.
- W2364809278 title "Association of HLA-DRB1, DQA1, DQB1 with uterine leiomyoma in women in southern China" @default.
- W2364809278 hasPublicationYear "2001" @default.
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