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- W2364823067 abstract "Nuclear envelope (NE) surrounding the periphery of the nucleus of interphase eukaryotic cells, is one of the characteristic biomembrane systems. It has been known that the contour of the nucleus of some malignant cells was not regular, and the perinuclear cisternae as well as the internal dense lamillae was thicker than that of the normal cells. These phenomena, however, are still lacking the quantitative informations.In this paper, the quantitative differences of the ratio of the surface area of NE to the volume of the nucleus (Sn) between the normal and tumor cells were demonstrated by the method of Cytomorphometric Analysis. The data indicated that Sn of ascitic hepatoma cells in the 6th day after inoculation was significantly greater than that of the normal liver cells by 40%. In other tumors inoluding both the ascitic and solid forms of Sarcoma 180 and Melanoma, Sn values were also higher than that of normal liver cells. While on the 2nd day after inoculation, ascitic hepatoma cells did not show the greater value of Sn. It suggested that the increase of transportational function of NE was associated with the proliferative status of the malignant cells. And it was found that the total thickness of NE had no significant difference between the normal and experimental tumor cells. Vincristine Homoharritonine have not demonstrated significant affection in these experiments, though the former induced slight lowering of Sn and thickness of NE of Sarcoma 180." @default.
- W2364823067 created "2016-06-24" @default.
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- W2364823067 date "1979-01-01" @default.
- W2364823067 modified "2023-09-25" @default.
- W2364823067 title "STUDIES ON NUCLEAR ENVELOPE I. THE QUANTITATIVE ULTRASTRUCTURAL ANALYSIS OF NUCLEAR ENVELOPE IN SEVERAL EXPERIMENTAL TUMOR CELLS" @default.
- W2364823067 hasPublicationYear "1979" @default.
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