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- W2364827785 abstract "Objective To explore the effects of RhoC-siRNA and Rapamycin on invasion and metastasis of hepatocellular Bel7402 carcinoma cell.Methods Bel7402 cells were randomly divided into seven groups:blank control group,negative plasmid group,RhoC-siRNA group,RhoC-siRNA combined with Rapa group,negative plasmid combined with Rapa group,Rapa group and solvent group.Different groups were treated with RhoC-siRNA,Rapa or RhoC-siRNA combined with Rapa.Cell cycle protein related gene was assessed by semi-quantitative RT-PCR.Metastasis of cells was determined through MMP-2,MMP-9,VEGF mRNA by RT-PCR.Cell migration was detected by Transwell.Results RhoC silence and Rapa significantly restrained metastasis and invasion of Bel7402.This effect was more significant in Rapa and RhoC-siRNA combination group.MMP2,MMP9,VEGF and CDK2 expression in RhoC-siRNA and Rapa group notably decreased,whereas P16 gene significantly increased(P0.05).The expression of MMP2,MMP9,VEGF and CDK2 in RhoC-siRNA and Rapa combination group decreased significantly,while P16 gene expression increased significantly(P0.05).RhoC-siRNA combined with Rapa significantly restrained Bel7402 migration(P0.01).Conclusion RhoC gene silencing or Rapa can inhibit Bel7402 cell invasion and metastasis.The combination of RhoC-siRNA with Rapa can further enhance this effect." @default.
- W2364827785 created "2016-06-24" @default.
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- W2364827785 date "2012-01-01" @default.
- W2364827785 modified "2023-09-23" @default.
- W2364827785 title "Effects of RhoC-siRNA combined with rapamycin on invasion and metastasis of hepatocellular carcinoma cell Bel7402" @default.
- W2364827785 hasPublicationYear "2012" @default.
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