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- W2364830152 abstract "Intracellular recordings were used on the cells of isolated guinea pig inferior mesenteric ganglion(IMG)to investigate the effects of bombesin(BOM) on the membrane potential and membrane resistance(Rm).The results were as follows:BOM(10 -5 *!mol/L) applied by pressure ejection induced dose dependent slow depolarizations in 84 0% of 181 IMG cells. The depolarizations were affected by Low Ca 2+ /High Mg 2+ solution but not blocked by cholinergic and adrenergic receptor antagonist. The Rm could be increased in 5 0%,decreased in 60 0% and nearly unchanged in the rest 35 0% of 80 depolarizations. In 8 3% of 181 IMG cells,BOM(10 -5 *!mol/L) evoked biphasic response consisting of an initial hyperpolarization followed by a slow depolarization. 7 7% of 181 IMG cells showed nearly no reaction to BOM. Applied by superfusion,BOM (10 -7 ～10 -6 *!mol/L,60*!seconds) also induced depolarizations in 90% of 10 IMG cells. The results above demonstrate BOM or its receptor may exist on guinea pig IMG cells and BOM depolarize most cells." @default.
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- W2364830152 date "2001-01-01" @default.
- W2364830152 modified "2023-09-25" @default.
- W2364830152 title "The Electrophysiological Effects of Bombesin on the Cells of Inferior Mesenteric Ganglion of Guinea-pig in Vitro" @default.
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