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- W2364831161 endingPage "962" @default.
- W2364831161 startingPage "953" @default.
- W2364831161 abstract "Introduction: Cholesteryl ester transfer protein (CETP) inhibitors substantially increase the concentration of high-density lipoprotein cholesterol (HDL-C), which may have a possible beneficial effect for cardiovascular disease risk reduction.Areas covered: Current data regarding the effects of CETP inhibitors on cardiovascular disease risk and possible mechanisms for their effects and safety are presented in this review.Expert commentary: The first CETP inhibitor, torcetrapib, was discontinued because of increased off-target adverse effects (increased serum aldosterone and blood pressure levels). The development program of dalcetrapib and evacetrapib, which were not associated with increased blood pressure, was terminated due to futility (insufficient efficacy) concerning cardiovascular outcomes. Although the failure of torcetrapib has been attributed to specific off-target effects, there are some common characteristics between CETP inhibitors pointing to the possibility that certain adverse effects may be class-specific. The newer CETP inhibitors anacetrapib and TA-8995 have promising effects on lipid profile and metabolism (increase of HDL-C and reduction of both low-density lipoprotein cholesterol and lipoprotein (a) levels), but their cardiovascular effects and safety profile have not yet been confirmed in large outcome trials." @default.
- W2364831161 created "2016-06-24" @default.
- W2364831161 creator A5009973021 @default.
- W2364831161 creator A5032218366 @default.
- W2364831161 creator A5063788798 @default.
- W2364831161 creator A5064886621 @default.
- W2364831161 date "2016-05-28" @default.
- W2364831161 modified "2023-09-27" @default.
- W2364831161 title "Cholesteryl ester transfer protein inhibitors: challenges and perspectives" @default.
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