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- W2364831493 abstract "Objective To study the changes and effects of ceramide, interleukin 1β(IL 1β) and caspase 3 in cerebrum after traumatic brain injury (TBI). Methods TBI models of rats were made with Feeney's method, and caspase 3 inhibitor z DEVD fmk,IL 1β antibody and ceramide degradation reagent sphingosine kinase(SK) were administered by intraventricular microinjections. The changes of water content, number of apoptotic cells, levels of IL 1β, caspase 3 and ceramide in brain tissues were monitored at 24 hours after TBI. Results After TBI, bilateral cerebral water content, TUNEL positive neuronal cells numbers, caspase 3, IL 1β, and ceramide expression in cerebrum increased significantly, z DEVD fmk decreased the number of TUNEL positive neuronal cells induced by TBI, and there was no effect on the production of ceramide and IL 1β. IL 1β antibody reduced the content of ceramide in cerebrum after TBI. It also decreased water content, the number of apoptotic cells, and caspase 3 in brain tissues after TBI, but its effects is not as notably as the effects of SK, and SK did not effect on IL 1β inducing in cerabrum after TBI. Conclusions The massive synthesis of brain ceramide is a very important medium in the secondary brain injury after TBI, and IL 1β is one of the factors that stimulate ceramide synthesis." @default.
- W2364831493 created "2016-06-24" @default.
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- W2364831493 date "2002-01-01" @default.
- W2364831493 modified "2023-09-24" @default.
- W2364831493 title "Study on changes of ceramide, interleukin-1β and caspase-3 in cerebrum after traumatic brain injury" @default.
- W2364831493 hasPublicationYear "2002" @default.
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