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- W2364831923 abstract "Objective To observe the regulatory effect of microRNA-21(miR-21)on the p38mitogen-activated protein kinase(p38MAPK)pathway and to investigate the molecular mechanism by which paeonol(Pae)inhibits injury of vascular endothelial cells(VECs).Methods VECs were isolated from rat thoracic aortas by collagenase digestion and adherent culture and then injured by oxidized low-density lipoprotein(ox-LDL);the cells were transfected with miR-21mimic or inhibitor using a HiPerFect transfection reagent.The protein expression of Ras,p-MKK3/6,and p-p38was measured by Western blotting;the level of tumor necrosis factor-α(TNF-α)in VECs was measured by enzyme-linked immunosorbent assay.Results The ox-LDL significantly increased the protein expression of Ras,p-MKK3/6,and pp38and induced secretion of TNF-αin VECs.Enhanced miR-21expression increased the level of TNF-αand protein expression of Ras,p-MKK3/6,and p-p38.Pae significantly reduced the release of TNF-αin injured VECs and inhibited the increase in TNF-αlevel and activation of p38 MAPK pathway caused by enhanced miR-21expression.Conclusion Pae can inhibit the miR-21-mediated p38MAPK pathway and reduce ox-LDL-induced release of TNF-αin VECs." @default.
- W2364831923 created "2016-06-24" @default.
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- W2364831923 date "2014-01-01" @default.
- W2364831923 modified "2023-09-25" @default.
- W2364831923 title "Paeonol Reduces Release of TNF-α in Vascular Endothelial Cells Induced by Oxidized Low-Density Lipoprotein through microRNA-21-mediated p38 MAPK Pathway" @default.
- W2364831923 hasPublicationYear "2014" @default.
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