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- W2364832083 abstract "Objective To explore the molecular biological mechanism of structural remodeling and the effection of Valsartan on atrial fibrillation(AF). Methods 51 rheunatic heart disease(RHD) complicated with AF patients undergoing valve replacement were enrolled in this study , including 23 patients taking the regular drug , 28 taking Valsartan and the regular drug .Before surgery, each patient’s figures of LAd, RAd, LVDd and LVEF were measured by ultrasonic cardiograph . The atrial samples were obtained during surgery for Western blotting to detect the p38 mitogen-activated protein kinase (p38MAPK)、AT1R and AT2R protein expression, and their apoptosis index were detected by TUNEL. Results Compared with the control group ,the patients taking Valsartan showed decreased p38MAPK、AT1R protein expression(P0.01)and increased AT2R protein expression(P0.01)in the atrium. Also the apoptosis index was showed decreased of patients taking Valsartan (P0.01).There are positively correlation between the apoptosis index and the left atrium dimension. Conculusion p38MAPK have been shown to play an important role in cellular apoptosis of patients with atrial fibrillation,and Valsartan may inverse the structural remodeling." @default.
- W2364832083 created "2016-06-24" @default.
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- W2364832083 date "2011-01-01" @default.
- W2364832083 modified "2023-09-26" @default.
- W2364832083 title "Effection of Valsartan on atrial structural remodeling and study on the mechanism with Patient of atrial fibrillaton" @default.
- W2364832083 hasPublicationYear "2011" @default.
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