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- W2364834668 abstract "Objective To identify the metabolites of scutellarin in plasma,bile,urine,and faeces samples of rats after ig administered with breviscapine.Methods To compare the plasma,bile,urine,and feces samples of rats after ig administered with breviscapine with those of rats of control groups by HPLC-DAD in a gradient elution way and identify the major metabolites by comparing their retention time and UV absorption with those of standard samples under the same HPLC conditions.Results Scutellarein-6-O-β-D-glucuronide (M5) was identified in rat plasma samples after ig administered with 20 mg/kg and 200 mg/kg breviscapine respectively;Scutellarein-6,7-di-O-β-D-glucuronide (M1),6-O-methyl-scutellarin (M3),scutellarein-6-O-β-D-glucuronide (M5),and scutellarin (M7) were identified in rat bile samples after ig administered with both 20 and 200 mg/kg breviscapine;Scutellarein-6,7-di-O-β-D-glucuronide (M1) was identified in rat urine sample after ig administered with 20 mg/kg breviscapine,and scutellarein-6,7-di-O-β-D-glucuronide (M1) associated with scutellarein (M2) and scutellarin (M7) were identified in rat urine sample after ig administered with 200 mg/kg breviscapine;Meanwhile,scutellarein (M2) was identified in rat feces sample after ig administered with 200 mg/kg breviscapine.Conclusion Scutellarin is metabolized extensively in rats after ig administered with breviscapine and the metabolites of scutellarin as the predominant form in vivo are mainly excreted in urine and bile of rats." @default.
- W2364834668 created "2016-06-24" @default.
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- W2364834668 date "2009-01-01" @default.
- W2364834668 modified "2023-09-23" @default.
- W2364834668 title "Identification of metabolites in plasma,bile,urine,and faeces samples of rats after ig administered with breviscapine" @default.
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