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- W2364838086 abstract "Objective:To investigate the gene and protein expressions of IK,Ach and reveal its underlying mechanism in Atrial fibrillation.Method:Right and left atrial appendages were obtained from 9 patients with chronic atrial fibrillation,and right atrial appendages from 13 patients were set as controls of sinus rhythm(SR)group,All patients underwent cardiac valve replacement surgery,the mRNA and protein expression level of Kir3.4 of the IK,Ach channel were detected with reverse transcription polymerase chain reaction(RT-PCR)and Western Blot.Result:The mRNA and protein expressions level of Kir3.4 of the IkAch channel are both much lower in AF group than in SR group,while no significant difference was found in left and right atrial tissue within the AF group itself.Conclusion:The decrease of GIRK4 of the IK,Ach channel in patients with AF is caused by the decreasing expression of the mRNA,and it maybe underlying the decrease of IK,Ach,which may indicate a compensatory response of atrium to chronic atrial fibrillation." @default.
- W2364838086 created "2016-06-24" @default.
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- W2364838086 date "2009-01-01" @default.
- W2364838086 modified "2023-09-23" @default.
- W2364838086 title "Expressions of muscarinic potassium channel in atrium from patients with atrial fibrillation" @default.
- W2364838086 hasPublicationYear "2009" @default.
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