Matches in SemOpenAlex for { <https://semopenalex.org/work/W2364846149> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2364846149 startingPage "1252" @default.
- W2364846149 abstract "BACKGROUND OBJECTIVE: The expression of some antigens has been involved in cytogenetic abnormalities in leukemia. This study was to explore the immunophenotypes of acute myelomonocytic leukemia (M4), analyze the correlation of M4 to cytogenetic abnormalities, and provide evidences for the diagnosis and therapy. METHODS: Immunophenotypic analysis was performed using a panel of monoclonal antibodies and three-color immunofluorescent staining methods of flow cytometry in 81 patients with M4 leukemia. Cytogenetic records of 73 patients were available, among which 35 were further investigated by dual-color interphase fluorescent in situ hybridization (FISH) and the immunophenotype of inv(16)-positive patients were analyzed. RESULTS: Among the 81 M4 leukemia patients, CD33 (84.0%) was the most commonly expressed antigen, followed by CD13 (81.5%) and CD14 (24.7%). CD34 was detected in 48(59.3%) patients. T lymphoid- and B lymphoid-associated antigens were expressed in 23 (28.4%) and 10 (12.3%) patients, respectively. All the 11 patients with M4Eo had CD13 expression. CD33, CD34, and CD2 were expressed in 10, 7, and 5 patients, respectively. Of the 14 patients with inv(16), 13 expressed CD13, 11 expressed CD33, 8 expressed CD34, 5 expressed CD14, 3 expressed CD7, and 3 expressed CD2. Of the 73 patients with cytogenetic records, 30(41.1%) had clonal chromosomal abnormalities. The expression of CD2 and CD34 was associated with karyotypic abnormalities. The expression of CD2 was higher in M4Eo patients, with no correlation to inv(16). CONCLUSIONS: Acute myelomonocytic leukemia mainly expresses myeloid lineage antigens. The expression of CD2 and CD34 is correlated to karyotypic abnormalities. The expression of CD2 is higher in M4Eo. Inv(16) exists in 40% of M4 patients and the expression of all the antigens has no correlation to inv(16)." @default.
- W2364846149 created "2016-06-24" @default.
- W2364846149 creator A5027475930 @default.
- W2364846149 creator A5040795581 @default.
- W2364846149 creator A5043831056 @default.
- W2364846149 creator A5061281909 @default.
- W2364846149 creator A5065661580 @default.
- W2364846149 creator A5080541120 @default.
- W2364846149 date "2006-10-01" @default.
- W2364846149 modified "2023-09-22" @default.
- W2364846149 title "Immunophenotypic and cytogenetic features of acute myelomonocytic leukemia" @default.
- W2364846149 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17059770" @default.
- W2364846149 hasPublicationYear "2006" @default.
- W2364846149 type Work @default.
- W2364846149 sameAs 2364846149 @default.
- W2364846149 citedByCount "1" @default.
- W2364846149 crossrefType "journal-article" @default.
- W2364846149 hasAuthorship W2364846149A5027475930 @default.
- W2364846149 hasAuthorship W2364846149A5040795581 @default.
- W2364846149 hasAuthorship W2364846149A5043831056 @default.
- W2364846149 hasAuthorship W2364846149A5061281909 @default.
- W2364846149 hasAuthorship W2364846149A5065661580 @default.
- W2364846149 hasAuthorship W2364846149A5080541120 @default.
- W2364846149 hasConcept C10205521 @default.
- W2364846149 hasConcept C104317684 @default.
- W2364846149 hasConcept C142724271 @default.
- W2364846149 hasConcept C147483822 @default.
- W2364846149 hasConcept C153911025 @default.
- W2364846149 hasConcept C174475383 @default.
- W2364846149 hasConcept C176290653 @default.
- W2364846149 hasConcept C196166836 @default.
- W2364846149 hasConcept C203014093 @default.
- W2364846149 hasConcept C2776863199 @default.
- W2364846149 hasConcept C2777542201 @default.
- W2364846149 hasConcept C2777928532 @default.
- W2364846149 hasConcept C2778461978 @default.
- W2364846149 hasConcept C2778608605 @default.
- W2364846149 hasConcept C2778729363 @default.
- W2364846149 hasConcept C2779282312 @default.
- W2364846149 hasConcept C2780007613 @default.
- W2364846149 hasConcept C2780817109 @default.
- W2364846149 hasConcept C28328180 @default.
- W2364846149 hasConcept C30481170 @default.
- W2364846149 hasConcept C54355233 @default.
- W2364846149 hasConcept C71924100 @default.
- W2364846149 hasConcept C86803240 @default.
- W2364846149 hasConceptScore W2364846149C10205521 @default.
- W2364846149 hasConceptScore W2364846149C104317684 @default.
- W2364846149 hasConceptScore W2364846149C142724271 @default.
- W2364846149 hasConceptScore W2364846149C147483822 @default.
- W2364846149 hasConceptScore W2364846149C153911025 @default.
- W2364846149 hasConceptScore W2364846149C174475383 @default.
- W2364846149 hasConceptScore W2364846149C176290653 @default.
- W2364846149 hasConceptScore W2364846149C196166836 @default.
- W2364846149 hasConceptScore W2364846149C203014093 @default.
- W2364846149 hasConceptScore W2364846149C2776863199 @default.
- W2364846149 hasConceptScore W2364846149C2777542201 @default.
- W2364846149 hasConceptScore W2364846149C2777928532 @default.
- W2364846149 hasConceptScore W2364846149C2778461978 @default.
- W2364846149 hasConceptScore W2364846149C2778608605 @default.
- W2364846149 hasConceptScore W2364846149C2778729363 @default.
- W2364846149 hasConceptScore W2364846149C2779282312 @default.
- W2364846149 hasConceptScore W2364846149C2780007613 @default.
- W2364846149 hasConceptScore W2364846149C2780817109 @default.
- W2364846149 hasConceptScore W2364846149C28328180 @default.
- W2364846149 hasConceptScore W2364846149C30481170 @default.
- W2364846149 hasConceptScore W2364846149C54355233 @default.
- W2364846149 hasConceptScore W2364846149C71924100 @default.
- W2364846149 hasConceptScore W2364846149C86803240 @default.
- W2364846149 hasIssue "10" @default.
- W2364846149 hasLocation W23648461491 @default.
- W2364846149 hasLocation W23648461492 @default.
- W2364846149 hasOpenAccess W2364846149 @default.
- W2364846149 hasPrimaryLocation W23648461491 @default.
- W2364846149 hasRelatedWork W14856111 @default.
- W2364846149 hasRelatedWork W2054384809 @default.
- W2364846149 hasRelatedWork W2111020946 @default.
- W2364846149 hasRelatedWork W2184118390 @default.
- W2364846149 hasRelatedWork W2211009138 @default.
- W2364846149 hasRelatedWork W2355878366 @default.
- W2364846149 hasRelatedWork W2359706699 @default.
- W2364846149 hasRelatedWork W2362328304 @default.
- W2364846149 hasRelatedWork W2364924448 @default.
- W2364846149 hasRelatedWork W2367092160 @default.
- W2364846149 hasRelatedWork W2371112915 @default.
- W2364846149 hasRelatedWork W2377296402 @default.
- W2364846149 hasRelatedWork W2377657824 @default.
- W2364846149 hasRelatedWork W2378372569 @default.
- W2364846149 hasRelatedWork W2383236559 @default.
- W2364846149 hasRelatedWork W2383687082 @default.
- W2364846149 hasRelatedWork W2393185549 @default.
- W2364846149 hasRelatedWork W2565936918 @default.
- W2364846149 hasRelatedWork W3141972135 @default.
- W2364846149 hasRelatedWork W3144956108 @default.
- W2364846149 hasVolume "25" @default.
- W2364846149 isParatext "false" @default.
- W2364846149 isRetracted "false" @default.
- W2364846149 magId "2364846149" @default.
- W2364846149 workType "article" @default.