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- W2364852016 abstract "Purpose To study the molecular cytogenetic alterations of the lung cancer with exfoliated cells in sputum samples by Fluorescence in situ Hybridization(FISH) analysis of chromosome-specific probes,and evaluate the possibility and validity of FISH in detecting of the lung cancer.Methods FISH was performed using 3,7,17 and p16,p53 of chromosome-specific probes to examine chromosome aberration of exfoliated cells in 40 sputum samples from patients suspected of having lung cancer.Results The frequency of numerical aberration of chromosomes 3,7,17 and p16,p53 was 41.9%,45.2%,41.9%,54.9% and 51.6% in sputum exfoliated cells.Loss of chromosome p16,p53 was the most common finding.As using the 5 chromosome probes in combination for detecting lung cancer,the sensitivity was 80.6%,the specificity was 77.8%,diagnostic concordance rate was 80.0%.Conclusions A number of chromosome aberrations are detected in the lung cancer by FISH technique which provides a basis for further understanding of its molecular pathogenesis,and can be used as an adjunctive tool for the diagnosis,prognosis of lung cancer." @default.
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- W2364852016 date "2012-01-01" @default.
- W2364852016 modified "2023-09-28" @default.
- W2364852016 title "Detection of chromosome number abnormalities by fluorescence in situ hybridization in sputum samples from patients with lung cancer" @default.
- W2364852016 hasPublicationYear "2012" @default.
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