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- W2364860165 abstract "Objective:To study the anticytokine Chinese herb combined with western drug and gene therapy on influence in the contents of IL-1β,TNF-α of degenerated cervical intervertebral discs in rabbits.Methods:Thirty-five four-month-old New Zealand rabbits(weight 2～3 kg) were randomly divided into seven groups:normal group,model group(shallow layer),model group(whole layer),drug group(shallow layer),drug group(whole layer),gene group(shallow layer),gene group(whole layer).In all groups except for the normal group,the cervical dynamic unbalance model of rabbits were made to induce to intervertebral disc degeneration.Seven months after operation,the drug groups were fed with Anti-hyperosteogeny capsule and Glucosamine Hydrochloride capsule twice a day for 1 month.The gene groups were infused recombinant plasmid DNA of TGF-β_1 in intervertebral discs of C_2-C_5,20 μl in each disc.After eight months,the contents of IL-1β and TNF-α of degenerated cervical intervertebral discs of every group were assayed with ELISA.Results:The contents of IL-1β and TNF-α in model group were raised,there was significantly difference as compared with control group (P0.05).The contents of IL1β and TNF-α in drug group and gene group were decreased,there was significantly difference as compared with model group (P0.05).Conclusion:The degenerated intervertebral disc releases many kinds of cytokine and inflammatory facters to accelerate the degeneration.Antihyperosteogeny capsule combined with Glucosamine Hydrochloride capsule and gene therapy have inhibition of the contents of IL-1β and TNF-α in degenerated cervical intervertebral disc." @default.
- W2364860165 created "2016-06-24" @default.
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- W2364860165 date "2005-01-01" @default.
- W2364860165 modified "2023-09-24" @default.
- W2364860165 title "Experimental study of the Anti-hyperosteogeny capsule(抗骨增生胶囊)combined with Glucosamine Hydrochloride capsule(葡立胶囊)and gene therapy on influence in the contents of IL1β,TNF-α of degenerated cervical intervertebral discs in rabbits" @default.
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