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- W2364861477 abstract "The recent discovery of JAK2 and/or MPL mutations in polycythemia vera(PV),essential thrombocythemia(ET),and primary myelofibrosis(PMF)has had a major impact on how we diagnose and treat these disorders.For instance,the presence of a JAK2 mutation is now considered necessary for the diagnosis of PV and the World Health Organization classification system has recently revised its diagnostic criteria for PV,ET and PMF to include JAK2 and MPL mutations as clonal markers.From the standpoint of treatment,JAK-STAT is now identified as a legitimate target pathway for drug development in myeloproliferative neoplasms.we will first outline the views regarding current management in ET,PV and PMF and then discuss emerging data on preclinical and clinical activity of anti-JAK2 small molecule drugs." @default.
- W2364861477 created "2016-06-24" @default.
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- W2364861477 date "2009-01-01" @default.
- W2364861477 modified "2023-09-26" @default.
- W2364861477 title "Essential thrombocythemia,polycythemia vera,and myelofibrosis:Current management and the prospect of targeted therapy" @default.
- W2364861477 hasPublicationYear "2009" @default.
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