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- W2364863767 abstract "In pithed rats,iv administration of 5-HT (100μg/kg)elicited the increase in diastolic pressure.L-THP(3~100 mg/kg.ia)dose dependently reduced the increase in diastolic pressure,and its ID50 value was 27 mg/kg and cyproheptadine was 65μg/kg.The increase in diastolic pressure evoked by NE was inhibited by L-THP also,and its ID50 value was 44 mg/kg.The antagonistic effects of L-THP to 5-HT (0.3~300μM),NE(0.01~100μM).and KCl (60 mM)were studied with the isolated rabbit pulmonary artery rings.Cyproheptadine,verapamil and phentolamine were sed as reference.L-THP shifted the cumμ-ulative concentration response curves for5-HT to right,and its pA2 value was 4.64.L-THP depressed the contraction induced by NE and KCl also.As to the anti-5-hy-droxytryptamine action,cyproheptadine was stronger than L-THP.As the anti-KCl action veraparnil was stronger.As for the anti-NE action,phentoamine was more specific.It is sugested that L-THP possesses anti-5-hydroxytryptamine action on thevessels,but its specificity is relatively low." @default.
- W2364863767 created "2016-06-24" @default.
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- W2364863767 date "1988-01-01" @default.
- W2364863767 modified "2023-09-26" @default.
- W2364863767 title "Effect of L-THP on contraction of blood vessels induced by 5-hydroxytryptamine" @default.
- W2364863767 hasPublicationYear "1988" @default.
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