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- W2364863793 abstract "Objective To evaluate the efficiency of 5 tumor biomarkers,namely carbohydrate antigen-125(CA-125), carbohydrate antigen-199 (CA-199),carcinoembryonic antigen(CEA), neuron-specific enolase (NSE), Cytokeratin 19(CYFRA21-1), independently or in combination for lung cancer diagnosis,pathological type and clinical stage. Methods Electrochemiluminesce-nce immunization was used to determine biomarker levels expressed in 309 patients with pulmonary disease. Results The observed levels of CA125, CA199, CEA, NSE and CYFRA 21-1 in patients with pathologically confirmed lung cancer were significantly higher than those in patients with benign pulmonary diseases. Adenocarcinoma, squamous cell carcinoma, and small cell lung carcinoma of the lung were associated with the highest sensitivity levels of CYFRA21-1 and CEA, CYFRA21-1, and NSE, respectively. The combination of 4 tumor biomarkers, namely, CAl25+CEA+NSE+CYFRA21-1 showed 87.26% sensitivity for lung cancer. The ROC of CYFRA21-1 was 0.840±0.032(95%CI,0.777-0.904). The positive rates and levels of CA125, CEA, CYFRA21-1 were different in clinical stages of lung cancer. Conclusion CA125, CA199, CEA, NSE and CYFRA 21-1 are valuable in the diagnosis, pathological type and clinical stage of lung cancer,especially CYFRA 21-1.The combination of CA125+CEA+NSE+CYFRA21-1 showed higher sensitivity for lung cancer. CA125, CEA, CYFRA21-1 play an important role in clinical stage." @default.
- W2364863793 created "2016-06-24" @default.
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- W2364863793 date "2013-01-01" @default.
- W2364863793 modified "2023-09-25" @default.
- W2364863793 title "Value of detection of serum tumor biomarkers in lung cancer diagnosis, pathological type and clinical stage" @default.
- W2364863793 hasPublicationYear "2013" @default.
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