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- W2364869902 abstract "Objective To investigate the correlation between infiltrating lymphoid cells and neoplastic cell apoptosis in nasopharyngeal carcinoma (NPC). Methods 38 untreated NPC biopsies were collected from the Department of Pathology, Sun Yat sen University of Medical Sciences. TUNEL (TdT mediated dUTP Nick End Labeling) method was performed for quantitating the apoptosis count (AC, numbers of apoptotic cell from among 5 000 NPC cells). DAKO LSAB kit (K 0681) and respective primary antibodies were used for detecting reactive T lymphocyte, monocyte/macrophage, pan B lymphocyte, and accessory dendritic cell immunohistochemically. The amount of infiltrating lymphoid cells was indicated in terms of TCI (T cell index), MMI (monocyte/macrophage index), BCI (B cell index), and DCI (dendritic cell index) by their cell numbers per one average high power field, respectively. Results ①The AC varied greatly from case to case in untreated NPCs, the mean value being (12.9±13.9)/5 000; ②The AC was both positively correlated with TCI (P0.05) and MMI (P0.05), but not with BCI (P0.05) and DCI (P0.05). Conclusions ①The infiltrating T lymphocytes representing cell mediated immunity are able to induce NPC cell apoptosis; ②The infiltrating monocytes/macrophages might principally be an apoptosis inducer or as a consequence of degraded apoptotic debris; ③The infiltrating B lymphocytes representing humoural immunity and antigen presenting dendritic cells as well are not directly correlated with NPC cell apoptosis." @default.
- W2364869902 created "2016-06-24" @default.
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- W2364869902 date "2000-01-01" @default.
- W2364869902 modified "2023-09-27" @default.
- W2364869902 title "Correlation Between Infiltrating Lymphoid Cells and Neoplastic Cell Apoptosis in Nasopharyngeal Carcinoma" @default.
- W2364869902 hasPublicationYear "2000" @default.
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