Matches in SemOpenAlex for { <https://semopenalex.org/work/W2364873387> ?p ?o ?g. }
Showing items 1 to 57 of
57
with 100 items per page.
- W2364873387 endingPage "325" @default.
- W2364873387 startingPage "314" @default.
- W2364873387 abstract "Background : Despite the advent of molecular biology and immunogenetics, the biologic behavior and disease entities of primary cutaneous B-cell lymphomas(pCBCL) have been undetermined. Moreover, rarity of pCBCL cases and the conflicting datas of current issues have contributed to the dilemmas in understanding of the biology of pCBCL. Until now, a study of the overall features of pCBCL in Korea has been rarely presented. Objective : We performed this study in order to identify the histopathologic and immunogenetic characteristics of pCBCL in Korea. Methods : The histopathologic, immunophenotypic and molecular analysis of preserved specimens of 15 cases with pCBCL were conducted. Results : 1. Of the 15 patients with pCBCL, most common types are follicle center cell lymphomas(73.3%). in REAL classification, diffuse large B-cell lymphoma is most common(66.6%). 2. In bcl-2 immunohistochemical staining, 3 cases(20%) were positive. 3. Only one of 15 cases of pCBCL denoted bcl-2 gene rearrangement by t(14;18) in minor cluster region. 4. Immunohistochemical staining demonstrated overexpression of p53 protein in 3(20%) of 15 cases. 5. 2 cases(13.3%) with point mutations(one for exon 5; the other for exon 8) in p53 DNA sequencing analysis. Conclusion : t(14;18) translocation may be rare in pCBCL in Korea. This finding indicates that bcl-2 expression by tumor cells in pCBCL without t(14;18) may occur by different genetic dysregulation. It seems to be that overexpression of p53 protein might not correspond with p53 mutations in pCBCL." @default.
- W2364873387 created "2016-06-24" @default.
- W2364873387 creator A5017469266 @default.
- W2364873387 creator A5020525736 @default.
- W2364873387 date "2003-01-01" @default.
- W2364873387 modified "2023-09-22" @default.
- W2364873387 title "A Histopathologic and Immunogenetic Analysis of Primary Cutaneous B-cell Lymphomas in Korea" @default.
- W2364873387 hasPublicationYear "2003" @default.
- W2364873387 type Work @default.
- W2364873387 sameAs 2364873387 @default.
- W2364873387 citedByCount "0" @default.
- W2364873387 crossrefType "journal-article" @default.
- W2364873387 hasAuthorship W2364873387A5017469266 @default.
- W2364873387 hasAuthorship W2364873387A5020525736 @default.
- W2364873387 hasConcept C142724271 @default.
- W2364873387 hasConcept C204232928 @default.
- W2364873387 hasConcept C2779338263 @default.
- W2364873387 hasConcept C2780942790 @default.
- W2364873387 hasConcept C71924100 @default.
- W2364873387 hasConcept C86803240 @default.
- W2364873387 hasConceptScore W2364873387C142724271 @default.
- W2364873387 hasConceptScore W2364873387C204232928 @default.
- W2364873387 hasConceptScore W2364873387C2779338263 @default.
- W2364873387 hasConceptScore W2364873387C2780942790 @default.
- W2364873387 hasConceptScore W2364873387C71924100 @default.
- W2364873387 hasConceptScore W2364873387C86803240 @default.
- W2364873387 hasIssue "3" @default.
- W2364873387 hasLocation W23648733871 @default.
- W2364873387 hasOpenAccess W2364873387 @default.
- W2364873387 hasPrimaryLocation W23648733871 @default.
- W2364873387 hasRelatedWork W1929604532 @default.
- W2364873387 hasRelatedWork W1969031094 @default.
- W2364873387 hasRelatedWork W2003265248 @default.
- W2364873387 hasRelatedWork W2017007462 @default.
- W2364873387 hasRelatedWork W2022110694 @default.
- W2364873387 hasRelatedWork W2025663531 @default.
- W2364873387 hasRelatedWork W2026479792 @default.
- W2364873387 hasRelatedWork W2030071549 @default.
- W2364873387 hasRelatedWork W2038217011 @default.
- W2364873387 hasRelatedWork W2079563332 @default.
- W2364873387 hasRelatedWork W2125175128 @default.
- W2364873387 hasRelatedWork W2155791494 @default.
- W2364873387 hasRelatedWork W2509976580 @default.
- W2364873387 hasRelatedWork W2516514836 @default.
- W2364873387 hasRelatedWork W2889190009 @default.
- W2364873387 hasRelatedWork W29500930 @default.
- W2364873387 hasRelatedWork W3134506825 @default.
- W2364873387 hasRelatedWork W3141922997 @default.
- W2364873387 hasRelatedWork W3154588245 @default.
- W2364873387 hasRelatedWork W3200160059 @default.
- W2364873387 hasVolume "41" @default.
- W2364873387 isParatext "false" @default.
- W2364873387 isRetracted "false" @default.
- W2364873387 magId "2364873387" @default.
- W2364873387 workType "article" @default.