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- W2364875314 abstract "OBJECTIVE:To study the effect and mechanism of all human serum amyloid A(SAA) family members on tumor metastasis.METHODS:Human SAA1-GST,SAA2-GST,SAA3-GST,SAA4-GST fusion proteins and GST protein were expressed and purified.Migration assay of LLC cells,Ba/mTLR4/mMD2cells and control Ba/κB cells by SAA1-GST,SAA2-GST,SAA3-GST,SAA4-GST and GST fusion proteins in vitro was used to study the effect and mechanism of SAA1-GST,SAA2-GST,SAA3-GST,SAA4-GST fusion proteins on tumor migration.RESULTS:Human SAA1-GST,SAA2-GST,SAA3-GST and SAA4-GST were expressed sucressfully.Human SAA1-GST,SAA2-GST,SAA3-GST,SAA4-GST,but not GST,significantly induced migration of LLC cells in vitro(P0.05).Human SAA1-GST,SAA2-GST,SAA3-GST,SAA4-GST,but not GST,significantly induced migration of Ba/mTLR4/mMD2 cells(P0.05) but not control Ba/κB cells in vitro(P0.05).pIkB protein was expressed significantly higher in LLC cells stimulated bySAA1-GST,SAA2-GST,SAA3-GST,SAA4-GST than that by GST(P0.05).CONCLUSION:Human SAA1,2,3,4 induce migration of tumor cells through TLR4 via NF-κB signaling pathway,which means that human SAA family might play a role in tumor metastasis." @default.
- W2364875314 created "2016-06-24" @default.
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- W2364875314 date "2010-01-01" @default.
- W2364875314 modified "2023-09-27" @default.
- W2364875314 title "Effect and mechanism of human serum amyloid A family on tumor metastasis" @default.
- W2364875314 hasPublicationYear "2010" @default.
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