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- W2364878885 abstract "Object To study the protective effect of Puerarin Oral Formulation (POF) on myocardial ischemia in rats and on cardiomyocytes of neonatal rats during hypoxia. Methods The experimental rats were randomly divided into the control group, the positive group (iv 0.033 5 g/kg Purerarin Injection before myocardial ischemia) and two POF groups (ig 0.8, 0.4 g/kg for 6 days continualy), myocardial ischemia rats were induced by posterior pituitary Pit injection. The normal ECG and the changed ECG of rats at 5, 15, 30 s, 2, 5, 10 min after giving Pit were recorded; The changes of cardiomyocytes form of neonatal rats in all groups were observed with microscope and the activity of LDH, CK, α HBDH in cell culture medium were assayed. Results Compared with the ECG of rats in control group, T wave, P R and Q T of ECG of rats in the treatment groups had significant difference; The activity of LDH, CK, α HBDH were inhibited by POF. Conclusion Myocardial ischemia caused by Pit in rats could be inhibited by POF. It shows that POF has protective effect on cardiomyocytes of neonatal rats during hypoxia." @default.
- W2364878885 created "2016-06-24" @default.
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- W2364878885 date "2003-01-01" @default.
- W2364878885 modified "2023-09-25" @default.
- W2364878885 title "Protective effect of Puerarin Oral Formulation on myocardial ischemia in rats and on cardiomyocytes of neonatal rats during hypoxia" @default.
- W2364878885 hasPublicationYear "2003" @default.
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