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- W2364888974 abstract "Objective:To explore the mechanism of malaria piperaquine resistance-associated immunomodulatory by detecting and comparing of dynamic changes of IFN-γ、TNF-αand IL-4's secreting cells in mice infected with the piperaquine resistant(PQR)line and the PQ sensitive(PQS)line of Plasmodium berghei(Pb)ANKA strain.Methods:80Kunming mice were divided into three groups of A(PbPQS),B(PbPQR)and C(normal control,NC)randomly.The numbers of spot forming cells(SFCs)of secreting IFN-γ,TNF-αand IL-4in mice splenocytes were determined by ELISPOTS.Results:On day 3and 6post-PbPQR or PbPQS infection,IFN-γSFCs displayed a significant increase in groups of A and B,it was higher in group A than those in group B(P=0.05)on day 3,but remarkably higher in Group B than those in group A(P=0.002)on day 6.The increasing TNF-αSFCs were significant higher in group B than those in group A(3d:P0.001,6d:P=0.037).IL-4SFCs in group A and B were increased with no statistical significance.Dynamic changes of three cytokine-secreting cells in group B during 22 days showed that there was a peak increase in IFN-γSFCs,TNF-αSFCs on day 6past-infection(pi),IL-4SFCs on day 9pi.Three kinds of cytokine SFCs increased again on day 22 pi.Conclusion:Th1immune response activated effectively in early stage of the infection and shifted to the Th2 immune response subsequently,and then synergistic antiprotozoal effects of three cytokines in late period of infection are important influencing factors for suppressing the parasitemia proliferation early,raising parasitemia rate later,and ultimate disease recovery in mice infected with PbPQR.The generation of PbPQR is close related with host immune." @default.
- W2364888974 created "2016-06-24" @default.
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- W2364888974 date "2015-01-01" @default.
- W2364888974 modified "2023-09-23" @default.
- W2364888974 title "Effect of IFN-gamma,TNF-alpha and IL-4's secretary cells from a murine model of Plasmodium berghei piperaquine resistant on the resistant related immune regulatory" @default.
- W2364888974 hasPublicationYear "2015" @default.
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